Zika virus — reigniting the TORCH

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Zika virus - reigniting the TORCH.

The recent association between Zika virus (ZIKV) infection during pregnancy and fetal microcephaly has led to a renewed interest in the mechanisms by which vertically transmitted microorganisms reach the fetus and cause congenital disease. In this Opinion article, we provide an overview of the structure and cellular composition of the human placenta and of the mechanisms by which traditional 'T...

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Is Zika Virus an Emerging TORCH Agent? An Invited Commentary

Zika virus (ZIKV) is a mosquito-borne arbovirus from the family Flaviviridae, which had caused some epidemics since its discovery in 1947 without any significant impacts on public health. In 2015, however, a 20-fold increase in congenital microcephaly cases in northeastern Brazil was attributed to prenatally acquired ZIKV infection. Traditionally, TORCH agents have 4 common characteristics incl...

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ژورنال

عنوان ژورنال: Nature Reviews Microbiology

سال: 2016

ISSN: 1740-1526,1740-1534

DOI: 10.1038/nrmicro.2016.125